Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine b-synthase-deficient mice
نویسندگان
چکیده
STEVEN R. LENTZ, ROCHELLE A. ERGER, SANJANA DAYAL, NOBUYO MAEDA, M. RENÉ MALINOW, DONALD D. HEISTAD, AND FRANK M. FARACI Veterans Affairs Medical Center, Iowa City 52246; Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa 52242; Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599; and Oregon Regional Primate Research Center, Beaverton, Oregon 97006
منابع مشابه
Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice.
Hyperhomocysteinemia is a risk factor for stroke, myocardial infarction, and venous thrombosis. Moderate hyperhomocysteinemia is associated with impaired endothelial function, but the mechanisms responsible for endothelial dysfunction in hyperhomocysteinemia are poorly understood. We have used genetic and dietary approaches to produce hyperhomocysteinemia in mice. Heterozygous cystathionine bet...
متن کاملEndothelial Dysfunction and Elevation of S-Adenosylhomocysteine in Cystathionine b-Synthase–Deficient Mice
Hyperhomocysteinemia is associated with increased risk for cardiovascular events, but it is not certain whether it is a mediator of vascular dysfunction or a marker for another risk factor. Homocysteine levels are regulated by folate bioavailability and also by the methyl donor S-adenosylmethionine (SAM) and its metabolite S-adenosylhomocysteine (SAH). We tested the hypotheses that endothelial ...
متن کاملEndothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Hyperhomocysteinemia is associated with increased risk for cardiovascular events, but it is not certain whether it is a mediator of vascular dysfunction or a marker for another risk factor. Homocysteine levels are regulated by folate bioavailability and also by the methyl donor S-adenosylmethionine (SAM) and its metabolite S-adenosylhomocysteine (SAH). We tested the hypotheses that endothelial ...
متن کاملInfluence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia.
OBJECTIVE Elevated plasma total homocysteine (tHcy) is associated with risk for cardiovascular disease. A common cause of mild hyperhomocysteinemia (HHcy) is folate deficiency. We sought to determine whether folate deficiency per se increases arterial permeability (quantitative fluorescence microscopy) and stiffness (vessel elastigraph), and whether the effects of folate deficiency are more sev...
متن کاملHomocysteine metabolism.
Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or betaine in an alternative reaction); and transsulfuration to cystathionine, which requires pyridoxal-5'-phosphate. The two pathways are coordinated by S-adenosylmethionine, which acts as an allosteric inhibitor of the methylenete...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000